Summary
In the Wano Country arc, Luffy finally awakened the true power of his devil fruit. The awakening of his devil fruit is dubbed Gear 5th, and it is quite different from any of his previous forms. While using Gear 5th, Luffy is able to extend his elasticity to inanimate objects.
Luffy’s devil fruit awakening allowed him to beat Kaido, who was considered the “Strongest Creature in the World.” In his Gear 5th form, there are not manyOne Piececharacters who can defeat him. However, there are plenty of other characters from other anime series who can defeat Gear 5th Luffy.

UPDATED on July 24, 2025, by Suzail Ahmad:As the main character of One Piece, Luffy’s development is never-ending. With every passing arc, Luffy grows stronger and more determined to claim the famed treasure that is One Piece. Luffy’s continuous development makes sense as his opponents' power scales with every arc.
At the moment, Luffy’s greatest power is Gear 5th. It has enabled Luffy to take on the likes of Kaido, Kizaru, and Lucci. In One Piece, only a handful of characters can stand up to his might. But the case is different when Luffy is compared to characters from other anime. With that in mind, here are more anime characters who can beat Luffy.
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19Lain Iwakura
Anime: Serial Experiments Lain
Lain Iwakura from Serial Experiments Lain is one of the strongest anime characters of all time. She has control over reality, and as a result, she can bend it to her will. Throughout the series, viewers watched her change what was real and what wasn’t.
On the surface, she appears to be a normal high school student, but the reality is far from that. Lain Iwakura can erase the memories of people throughout the universe. Additionally, she can erase a person from existence and replace them with a clone. Above all, Lain Iwakura can reset the universe and mold it however she desires. With all these abilities, Luffy stands no chance of beating her.

Usagi Tsukino is the main character of Sailor Moon. She is one of the most powerful anime characters of all time, yet her name is rarely mentioned in such debates. She has the strength to nullify space-time techniques, a feat only some individuals can boast of. Usagi can shatter dimensions with her supersonic waves, something that no One Piece character is capable of doing.
She can also limit her opponents' actions by trapping them in space-time vortexes. Due to the nature of these attacks, it is nearly impossible to avoid them. Usagi also has the power to heal, which allows her to fight even after sustaining multiple wounds.

Skull Knight is a mysterious swordsman who openly opposes the God Hand. At some point in the past, the Skull Knight donned the Berserker Armor before shifting to the current one. As one of the oldest beings in Berserk, the Skull Knight is knowledgeable about a lot of things.
Since he has been fighting the God Hand and their goons for such a long time, it is rather obvious that the Skull Knight possesses monstrous strength. He wields a sword made entirely of Behelits. A slash from the sword is strong enough to open up dimensional rifts and shred humongous apostles to pieces.

The Disastrous Life of Saiki K.
Saiki Kusuo is the main protagonist ofThe Disastrous Life of Saiki K. He might not be as famous as some of the other anime characters on the list, but there is no denying that he is an extremely powerful character. Saiki possesses a variety of powers, which include hypnosis, clairvoyance, mind control, petrification, telekinesis, etc.
With the help of these powers, Saiki can easily crush his opponents. Luffy’s Gear 5th is strong in its own right, but it won’t be sufficient to defeat someone like Saiki.

Yhwach was one of the primary antagonists inBleach. He had an interesting persona, which made him stand out from the rest of the characters in the story. Yhwach was blessed with several noteworthy abilities, but the one that stood out the most was the Almighty.
It gave him the power of precognition, with which he could see multiple futures. He could use it to his advantage by planning his next phase of action accordingly. Yhwach could also set up traps to catch his enemies off guard, therefore altering the future in the process. Moreover, Yhwach can absorb other individuals, which gives him access to their knowledge and power.

Alucard is the main character from Hellsing. He is an immensely powerful individual who has killed hundreds, if not thousands, of people over the years. Every battle that Alucard participated in helped him become stronger. With every fight Alucard’s experience continued to increase, and so did his control over his powers.
Alucard’s regeneration powers make him almost impossible to kill. He can regenerate from all kinds of wounds, no matter the severity. Alucard has several other abilities in his locker, which include telepathy, teleportation, hypnosis, soul absorption, etc. With so many powers at his disposal, Alucard should have no problem taking down Gear 5th Luffy.

Mereum was the king of the Chimera Ants. He was ruthless and arrogant, believing that all other races were inferior to him. Due to this reason, Mereum had no qualms about killing and cannibalizing members of his own race. If someone dared to question his authority, Mereum would immediately shut them down.
Mereum was blessed both physically and mentally. He was able to learn and master all of his abilities in next to no time. Furthermore, Mereum’s physical abilities allowed him to compete with the likes of Isaac Netero, the strongest Hunter of his time, effortlessly. In a fight to death, Mereum would have absolutely no problembeating Luffy.

Gilgamesh is one of the main antagonists of theFateseries. When he was still alive, he used to rule the city of Uruk. He strongly believed that he was superior to everyone else. Due to this reason, Gilgamesh placed himself before the people of his own kingdom.
Gilgamesh possesses the Gates of Babylon, a Noble Phantasm that grants him access to all his collected treasures. Gilgamesh’s most trusted Noble Phantasms are Enkidu and Ea. Enkidu allows him to bind his targets in place while Ea can finish them off.

Sinbad used to be the king of Sindria, and he was quite popular among his subjects. He is an easygoing individual, but he can be serious if needed. While Sinbad is a talented swordsman, it is his Magoi manipulation that makes him a dangerous opponent.
Sinbad can use his own Magoi to cancel out the effects of his target’s abilities. He also has seven Djinns in his possession, each of which grants him a specific ability. With so many different weapons at his disposal, Sinbad can definitely defeat Luffy.
Artland
Shotaro Mizuki
Akuto Sai is the primary protagonist ofDemon King Daimao. He had the desire to become a high priest so that he could be of service to the people around him. So he joined the Constant Magick Academy to realize his dream. Not long afterward, a spirit predicted that Akuto Saiwould become a Demon King.
However, he didn’t let it get to his head. Akuto focused on being kind and generous to everyone he met. With time, Akuto became the Demon King and gained incredible power. He has a large amount of magic reserves, which he can use to obliterate his opponents. Akuto Sai is capable of altering reality, so it wouldn’t be a problem for him to defeat Gear 5th Luffy.