Serumis a survival, crafting, and exploration game that features a variety of different serums for players to use. Each one provides different effects useful for combat, survival, and traversal ofSerum’s gloomy and atmospheric game world. Although options are limited inthe early game, there are still some choices to be made when equipping Adam, the protagonist, with serums.
While it’s possible to stack serum effects, doing so produces more Human Distortion, which can prevent Adam from healing, so it’s not always the best choice. Here are the best early game serums, accounting for availability, level of distortion produced, and any abilities or powers they provide.

10Tether Serum
Useful Combat Power
The Tether Serum is an essential serum in any tester’s toolkit. Combat inSerumcan be quite difficult, especially at the start of the game, and the active serum Tether is a great way to level the playing field.
When Adam uses Tether, woody vines grow from the ground to entangle any enemies around him, giving the player room to breathe and an opportunity to attack. Used as a singular effect the Tether Serum only costs +10 Human distortion, too, making it a cheap way to gain an active power.

9Health Restoration Serum
Basically A Healing Potion
Health Restoration is an excellent effect that can help keep Adam alive longer. It’s essentially abasic healing potion. The Health Restoration effect can be used in conjunction with other serum effects making it a good choice to round out a particular serum - particularly with the Blight Protection effect.
Not as flashy as some other serums, Health Restoration Serum is very useful in the early game when it feels like enemies hit harder and take a while to go down.

8Destructive Leap Serum
Area Effect Damage
Destructive Leap is an incredibly useful ability that allows Adam to jump up and crash into the ground, letting off a shockwave that stuns nearby enemies.
This is an extremely effective ability that’s available very early on in the game, making it an easy choice of effect to use in a serum.

7Weapon Damage Serum
Free Extra Damage
The Weapon Damage Serum is an extremely useful serum and serum effect. It grants additional damage to Adam’s weapons but doesn’t have a Distortion cost, making it essentially free to use.
Weapon Damage is a great effect to combine with other effects to make even more potent serums, but the Weapon Damage Serum is a great choice on its own precisely because it doesn’t cost Distortion and can be used as and when necessary.

6Antifog Serum
Fog-Be-Gone
The game world ofSerumis a harsh one filled with mutated plants, animals, and even a dangerous toxic mist. Even with blight protection, the toxic mist inSerumis deadly to protagonist Adam, effectively blocking the player fromtraversing locationsinside the mist.
Fortunately, there is a type of serum that grants 100% protection from the toxic mist. Antifog Serum is an essential serum for any player to carry around, whether on its own or as a combined effect with another serum.

5Blight Protection Serum
More Time To Live
The Blight Protection Serum is the basic serum Adam can craft and sometimes find in the world, but it’s an incredibly useful serum. InSerum,Adam only has a limited amount of time he can survive in the world without protection from the Blight.
Blight Protection Serum grants five whole minutes of Blight protection and can be stacked, at a cost of only 33 Human Distortion. This is larger than some other serums, but it’s an absolutely essential expenditure and is a lot better than simply eating raw ingredients for minuscule boosts.

4Blight Protection + Antifog Serum + Healing Serum
Antifog, Antiblight, Nice Healing
This serum packs a whole lot of punch, granting five minutes of blight protection, ten minutes of Toxic Mist resistance, and 100 healing. This is really great utility, but it does come at quite a steep cost.
+53 Human distortion is a lot to pay for the effects, but sometimes it’s worth it for the all-in-one effect.

3Blight Protection + Healing Serum
Fantastic Basic Serum
The Blight Protection and Healing Serum is a great choice of serum to use after a fight. Some fights inSerumcan last a little while, especially in the early game, so at the end, it’s easy to run out the Blight protection timer and be in need of a little healing.
Thankfully, this two-for-one serum can do both. Using it extends both the Blight protection timer and grants healing, giving Adam - and the player - a little extra room to breathe.

2Tether + Destructive Leap + Blight Protection Serum
All-In-One Blight Protection And Utility
The combination of the Tether, Destructive Leap, and Blight Protection effects is an extremely useful one during the early part ofSerum.Tether and Destructive Leap offer great combat utility, while protection from Blight is always a plus inSerum’sharsh world.
As a nice bonus, the Tether and Destructive Leap abilities last until death or the use of the Absorber, making them a much more medium-term effect than many others.

1Resistances Serum
Three Resistances in One
Combat inSerumcanbe quite challenging, and there are times that Adam feels quite squishy. Fortunately, there is a solution to that problem: a serum specifically designed to increase Adam’s resistance to damage.
This is a nice effect, and it’s also pretty cheap in terms of the Distortion it causes, although its ingredients are a little more annoying to gather than some other serums. Still, it’s a great choice for any player who’s feeling a bit fragile.